From the south or south-east
(Motorway N3 from Chur, Sihltal from Gotthard, Luzern).
Follow the motorway N3 until the end. Then following the signs towards Winterthur, St.Gallen and Flughafen Kloten you will cross the Limmat Valley on the EscherWyss Bridge and go straight up the hill to the top. There you should see a sign directing you to the right to "Uni Irchel - Parkhaus" , the Campus underground parking lot, where you can leave your car.